Wincef Vial 1gm

Indication :

Adults:

WINCEF is indicated in the treatment of the infections listed below when caused by susceptible bacteria.

• Lower respiratory tract infections, including pneumonia and bronchitis.

• Urinary tract infections, both complicated, including pyelonephritis, and uncomplicated infections.

• Skin and skin structure infections.

• Intra-abdominal infections, including peritonitis and biliary tract infections.

• Gynaecological infections.

• Septicaemia

• Empiric treatment in febrile neutropenic patients (See PRECAUTIONS) WINCEF is also indicated for surgical prophylaxis in patients undergoing intraabdominal surgery. In this indication it is essential that metronidazole also be administered.

Paediatrics:

WINCEF is indicated in paediatric patients over 2 months of age for the treatment of the infections listed below when caused by susceptible bacteria:

• Pneumonia

• Urinary tract infections, both complicated, including pyelonephritis, and uncomplicated infections

• Skin and skin structure infections

• Septicaemia

• Empiric treatment in febrile neutropenic patients (See PRECAUTIONS)

Culture and susceptibility studies should be performed when appropriate to determine susceptibility of the causative organism(s) to cefepime. Empiric therapy with WINCEF may be instituted before results of susceptibility studies are known; however, once these results become available, the antibiotic treatment should be adjusted accordingly.

Because of its broad spectrum of bactericidal activity against gram-positive and gram-negative bacteria, WINCEF can be used appropriately as monotherapy prior to identification of the causative organisms(s). In the treatment of febrile neutropenia, consideration should be given to the need for other antibiotics in combination with WINCEF. In patients who are at risk of mixed aerobicanaerobic infection, including infections in which Bacterioides fragilis may be present, concurrent initial therapy with an anti-anaerobic agent is recommended before the

causative organism(s) is known.

Composition :

Cefepime hydrochloride is a semi-synthetic, broad spectrum cephalosporin antibiotic for parenteral administration.

Cefepime hydrochloride is a white to pale yellow powder. It is highly soluble in water.

WINCEF powder for injection is a sterile dry mixture of Cefepime hydrochloride and L-arginine. It is supplied in vials containing Cefepime hydrochloride equivalent to Cefepime 500 mg, 1 g and 2 g.